UNC5D _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017347
Fusion event
HBV-UNC5D integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1841
End
1932
Integrated sequence
CATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAG
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
35111281/35253763 (Hg38)
End
35111381/35253863 (Hg38)
Location type
Intron
Target gene
UNC5D
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-4328 ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-124-1/Upstream/5296415; hsa-mir-10400/Downstream/6017185;
Nearest TSS
ENST00000518652/Upstream/17988; ENST00000474634/Downstream/290529;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/17170, chr8-CpG: 351/Downstream/2440563
Nearest cancer related gene
UNC5D(TSG, No orient, 0)
Upstream sequence
ATTGTTTATGATTTGAAAACTTTCAGGCAAAATCCAATTTACATTTTTCCCTTCCCTAGCAATTACTTTTTTCCAGCTTCAACTCTTCTTAGTTACTAAT
Downstream sequence
GCAATGTCACCTTCATCATTTATGAAGGTTGCACATATACATGGGAATTTTTTAGTCTGGCATTAAATGTTCTTCAAAAGAGTTCCTGCAAACGTTTTTG
Target sequence
taggtgtgagccaccacgtggcctcatttcattctttcatgtggataggcagttgttccagaagtatatagtgaggagcttcttctttctctaatgATCT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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