Basic Information
VIS ID
TVIS10017348
Fusion event
HBV-chr10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2312
End
2385
Integrated sequence
CCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCT
Host Sequence
Chromosome
chr10
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
30212820/29923891 (Hg38)
End
30212902/29923973 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/321545; hsa-mir-107/Downstream/444624;
Nearest TSS
ENST00000439456/Upstream/187110; ENST00000375322/Downstream/89945;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/186743, chr10-CpG: 124/Downstream/134697
Upstream sequence
caatttgacttcctcttttcctaatttaataccctttatttctttctctgcctgactgccctggccagaacttccaacactatgttgaataggagtggtg
Downstream sequence
CTGATAATTAGGGAAAGGAAGCAGGTAAGTTGGAAATCCTGTGAGATCATGGCAAAGTGGAACAACATTTCTCCCTGTCCTATTTCTTGTTTCTTCTTCC
Target sequence
AGTGGCATAGACTCCCAGCTGAAAACATTTTCACTTGGCAAATGGAAGACCATGAAAGAAAACCTGGCCATGCTGTAGGGTC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate