Basic Information
VIS ID
TVIS10017350
Fusion event
HBV-chr17 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1219
End
1313
Integrated sequence
CATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTG
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
12183934/12280617 (Hg38)
End
12184037/12280720 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/198621; hsa-mir-10226/Downstream/636548;
Nearest TSS
ENST00000595228/Upstream/79017; ENST00000577679/Downstream/269062;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/259063, chr17-CpG: 70/Downstream/384630
Upstream sequence
gttGAGTGAATCAATAAATACTCATtgagtgaatgagtgaatgaatgaataaaATGGAAATCTGAAGAATGAGTAGGTATTATCCAGTTAATATGCCACC
Downstream sequence
CAGATCAAAGGAGATTAAGTTGAAGTGCATCCCTCTTTAGTGAAGCACTTGGCAAATGTCTCAATTCTTTTAGAGATGATTTTGAGTTTTGTAGAATTAA
Target sequence
CTGGGGACACTGAGGCTGTGCAGTGTCATGATGGGAGGCATTCACAAGGTTCTGCAAAATATAGCGAATAGCCAGCCATTTGGATTACCCTGACTCTGCAGAT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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