Basic Information
VIS ID
TVIS10017351
Fusion event
HBV-chr17 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1260
End
1350
Integrated sequence
TGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCT
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
12216447/12313130 (Hg38)
End
12216546/12313229 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/231134; hsa-mir-10226/Downstream/604039;
Nearest TSS
ENST00000595228/Upstream/111530; ENST00000577679/Downstream/236553;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/291576, chr17-CpG: 70/Downstream/352121
Upstream sequence
tattcttcctttctttatgtagatctgagtttctaacctatatcattttccttatctctaaagaatttcctttaacatttcttacaaggcaggtctactg
Downstream sequence
gtttggctggatatgaaattcttcattggaagttctgttttgttttttttttttttaagaatgttgaatataggcccccaatctcttctcgcttgtaggg
Target sequence
ccttaaggacttcttataaggtgggtctcttggtaaaaaattcctttagcatttgcttatctgaaaaggatcttgtttctccttcacttgtaaagctta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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