Basic Information
VIS ID
TVIS10017355
Fusion event
HBV-chr19 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
867
End
949
Integrated sequence
CTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTT
Host Sequence
Chromosome
chr19
Cytoband
q11
Reference genome
GRCh37/hg19
Start
27732102/27241194 (Hg38)
End
27732191/27241283 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/6841840; hsa-let-7e/Downstream/7881417;
Nearest TSS
ENST00000633603/Upstream/3094493; ENST00000588318/Downstream/399355;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3269237, chr19-CpG: 42/Downstream/552337
Upstream sequence
CTGTTCATCTTGCCCGGCTCCCACTTCACAGCTCACACTGGTATAGTGTGGCCCCCTCCTCTTCTAGTATTTCCATGTGTAGCCTCACAAGATAACTGGC
Downstream sequence
tgaggtcagtggtagaaaaggaaatatcttcgtataaaaactagacagaatgattctcagaaactgctttgtgatgtgtgcgttcaactcacagagttta
Target sequence
ttcaactcacagagttgaacggttctttacacagagcagatttgagacactctttttgtggaatttgtaagtggagatttcagccgctt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate