Basic Information
VIS ID
TVIS10017358
Fusion event
HBV-chr1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1349
End
1433
Integrated sequence
CTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCC
Host Sequence
Chromosome
chr1
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
121485245/121743447 (Hg38)
End
121485346/121743548 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4648719; hsa-mir-1182/Downstream/24107039;
Nearest TSS
ENST00000473358/Upstream/162923; ENST00000443018/Downstream/21756964;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/223720, chr1-CpG: 312/Downstream/3341961
Upstream sequence
AGGAGGGATGGGAGGGTGGGGGTGGTCCTTGGCCTGGGAAGGAAAACTCCACCAGGCCTTCGGAGCTGGGCACGCCCTGTTCCCACAATTAAGAAAAAAA
Downstream sequence
ttgtaaagtctgcaagtggatattcagacctccttgaggccttcgttggaaacgggatttcttcatattctgctagacagaagAATTCNNNNNNNNNNNN
Target sequence
gaaacaagacagaatgattctcagaaactcctttgtgatgtgtgcgttcaactcacagagtttaacctttcttttcatagagcagttaggaaacactctgt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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