Basic Information
VIS ID
TVIS10017359
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
3080
End
3171
Integrated sequence
CCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGC
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
41263889/41406370 (Hg38)
End
41263989/41406470 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/135227; hsa-mir-10400/Downstream/253971;
Nearest TSS
ENST00000518652/Upstream/96873; ENST00000521725/Downstream/28828;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/96749, chr8-CpG: 69/Downstream/83805
Upstream sequence
TCTGAGTGAAGATAGCAGGGATGCTGTGTTCACCCTTCTTGGTAGAAGCTAAGGTGTGAGCTGGGAGGTTGCTGGACAGGATGGGGGACCCCAGAAGTCC
Downstream sequence
TGAAATCTAACAAGCTCTGTAACATTGTGGCTCTGATTGACAAGACTGAGGATCCCAACTTTGACCTATCAGCTATCACCCTTCCTTTGCCCACTGCTTA
Target sequence
aaggaaatgagtgtattaagtgaacaccaacaataagctggaacccatatcctcttactcctaattgcatgctcttccaacacaccccactttgcctGTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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