Basic Information
VIS ID
TVIS10017360
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
416
End
508
Integrated sequence
GCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCAC
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
41264358/41406839 (Hg38)
End
41264459/41406940 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/135696; hsa-mir-10400/Downstream/253501;
Nearest TSS
ENST00000518652/Upstream/97342; ENST00000521725/Downstream/28358;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/97218, chr8-CpG: 69/Downstream/83335
Upstream sequence
AAATATCCTGGACAGATTCCAGAAATTTCAAATAAATATCTTTTTCATAAATATTTTGATGTGTATGATCTAGTCATAAAGAATATTTTACCGCCAAAAA
Downstream sequence
ggacttacagttccacgtggctggggaagcctcacaatcatggcgtaaggcaaggaagagcaagtcgcatcttacatggatggcggcaggcaaaaggaga
Target sequence
AGACCCCAGTGGGAAGCTGACCCTGtgtattagtccattttcacgctgctgataaagacgtacccgagactggtcaatttacaaaagaaagaggcctaatt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate