Basic Information
VIS ID
TVIS10017361
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1720
End
1811
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
46393435/46390328 (Hg38)
End
46393535/46390424 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/12226655; hsa-mir-11401/Downstream/3902192;
Nearest TSS
ENST00000527434/Upstream/10603441; ENST00000569239/Downstream/193829;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10287615, chr16-CpG: 124/Downstream/37034
Upstream sequence
gagcttgcagtgagccgagatcgtgccactgcactccagcctgggcgacagagcgagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaagaGGA
Downstream sequence
atgattccgtacgattccattctgtgatgattccatgtgattgcattcaatgatgattcctttagattgcattcgatTGTGATTCACTTCGTCTTCATTC
Target sequence
cgatgatgatttcattcgagtccattcgacacttccaatcgattccatttgatgtttccattcgagtccaattgatgattccattcaattccattcgatg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate