Basic Information
VIS ID
TVIS10017362
Fusion event
HBV-IGK integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1938
End
1988
Integrated sequence
GTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGAT
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
89872076/89833266 (Hg38)
End
89872133/89833323 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
IGK
Nearest miRNA
hsa-mir-1285-2/Upstream/1020812; hsa-mir-10b/Downstream/6964955;
Nearest TSS
ENST00000437798/Upstream/502837; ENST00000429992/Downstream/18468;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/65165, chr2-CpG: 65/Downstream/404725
Upstream sequence
ACTCGTACCCTCTCTACGCCATCTACCTCATCGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTGTCCTTAAGGTTCATCAAACAGAAACC
Downstream sequence
attccattccactcgtgttgattccattccattccattcaactccgttccattccattccattccattccattccattccattccattccactcagattg
Target sequence
ccattccattccattcctgttgattccattccattgcattccattccattccattcc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate