Basic Information
VIS ID
TVIS10017363
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1690
End
1777
Integrated sequence
ACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAG
Host Sequence
Chromosome
chr4
Cytoband
p11
Reference genome
GRCh37/hg19
Start
49105924/49103907 (Hg38)
End
49105996/49103979 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1451164; hsa-mir-1243/Downstream/3608703;
Nearest TSS
ENST00000502981/Upstream/75215; ENST00000504661/Downstream/2739021;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/117116, chr4-CpG: 24/Downstream/57461
Upstream sequence
TTTTTTGAGATTCAGCTGGCTTCTTCTGAGCTTCTTTTTCTGCTTCATCCACATGAATGGTGAACGCAGGCTGTTTACTGTTTGCTTTCCAAGGAGGAAC
Downstream sequence
cccttacactcaggttgattccgctccattccattgcattacattccatttcattccactcgggttgattcctttctattccattcaattccactcgggt
Target sequence
ttccattccgttccattccattcgggttgattccattccattccattccattccattccattccattccatt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate