Basic Information
VIS ID
TVIS10017367
Fusion event
HBV-LOC101927506 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1314
End
1400
Integrated sequence
GAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACT
Host Sequence
Chromosome
chr8
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
122999/172999 (Hg38)
End
123098/173098 (Hg38)
Location type
Intronic
Target gene
LOC101927506
Nearest miRNA
hsa-mir-10400/Downstream/1628027;
Nearest TSS
ENST00000518652/Upstream/5956; ENST00000610248/Downstream/59039;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/89505, chr8-CpG: 25/Downstream/55903
Upstream sequence
AATGCCTTAAAATGTTTTTCTTCTTCAGTATTTTAAGGACTTTTCTTTATTTTCTTCCCAGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGACA
Downstream sequence
GTAAAAACCCAAAGGATTGGTGACTTATCACAGCTGGAGTGAATACGAAGGAGCATGAACTCAAAGAAAATATCAAGATTTAAGCAAGAATAAATAGGAC
Target sequence
AAGATTGAAATAGAGCAGACTTGGGGGGCTACACAGAGGAACTGGGACTACACAGTTCCAGCTTTAAGGCTATAGAAACAGAAATAGATATACTGGTAA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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