Basic Information
VIS ID
TVIS10017368
Fusion event
HBV-LOC107984125 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
193
End
281
Integrated sequence
TCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTA
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
55721980/54809420 (Hg38)
End
55722077/54809517 (Hg38)
Location type
Intronic
Target gene
LOC107984125
Nearest miRNA
hsa-mir-124-1/Upstream/11913145; hsa-mir-10400/Downstream/6905271;
Nearest TSS
ENST00000518652/Upstream/193353; ENST00000522559/Downstream/292872;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/187947, chr8-CpG: 222/Downstream/291579
Upstream sequence
TTTTGGACAGTGTGCTTGAAGCCTAGAAGCCTCAGAGGTAAAACCTGTAACTCTATCCCTACAGATGTGCTATGTGGAGATTCTCATGTCCCAGCTTTAT
Downstream sequence
TTCATAAAAGCCTTAAATTCAAACAAATTCTCTGTATGTATTTCAATCTTATGCCAGAAAGACATGCTGTACATAAAAAAAGACTGTTTCTTTCACAGCC
Target sequence
GGTTCAGTGGCAGAGATGGAGTCGACTGCTGGCATCTGAATTATGTATTAATAAAAGTTAGATTCATGCAGTATGCTAGTAGTAGCAGACTGTGTTG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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