Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017371
Fusion event
HBV-IL23R integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
2911
End
3002
Integrated sequence
AGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCAT
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
Start
End
67675686/67210003 (Hg38)
Location type
Intron
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-4777-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6787-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-6736-3p ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-6854-5p ; hsa-mir-130a-3p ; hsa-mir-216a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/581395; hsa-mir-11399/Downstream/973515;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/74880, chr1-CpG: 139/Downstream/219449
Upstream sequence
atcgcaccactgcactccagcctgggcgacagagtgagactccgtctcaaaaaaaataaaataaaataaaataagctgggtatggtggcccacacctcta
Downstream sequence
AAAATTGTTCGGAAAGGAGAACTAAGATGTATGAATGTTTCTTTTTAAGTGAAAAGTGTATAGTTCAGAGTGTAATATTTATTACCAGTATAGGCCTGAG
Target sequence
CAGTGTCTCCTAGGGTGAAATTTATATCAGTGATCATGGATAAAAAATTTAAGTATTCTGTGCTGAAATTTGACAGGCATCCAGGGAAACA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.