Fusion event
HBV-IL23R integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
GGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGT
End
67675809/67210126 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-101-1/Upstream/581511; hsa-mir-11399/Downstream/973392;
Upstream sequence
AAGAAAGATGAGGGGCCAGCACCCCACCCTCCCCAGGGTTGTTGACTCCTGCTGGTACTGGCTGTGGCTGAAGTCATCATCATGGAGGCTAACCCTTGGA
Downstream sequence
GATAATCCGAGTAAAAATGAGTTTAAAAAAGTGAACGTCTAGAGAAACAAACTAACCATCCTTAAATGCCAAGGTTAAATTATCTAGTGTCTTAAGAAAG
Target sequence
GATGTATGAATGTTTCTTTTTAAGTGAAAAGTGTATAGTTCAGAGTGTAATATTTATTACCAGTATAGGCCTGAGTCTTAGGTGAGCTTAAAGATGAT
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.