Fusion event
HBV-BET1L integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
GTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7a-2/Downstream/33795;
Upstream sequence
TACTTAAATATTTTAGGAAAAAGGATTTGCACTCTTGAACTTAATGCACAAAGCCCTTTAAGATTTTATCCCTACTTGACCCCACAGTTTTTCCCACTCC
Downstream sequence
cgctaaccctaaccctaaccctaatcctaaccctaaccctaaccctaaccctaaccctagcccctaatcctaaccctaacccctaacccctaatcctaac
Target sequence
accctaaccctaacccaaccctaaccctagcccctaatcctaaccctaacccctaacactaaccctaaccctaacgctaa
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.