Basic Information
VIS ID
TVIS10017379
Fusion event
HBV-chr22 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2270
End
2356
Integrated sequence
AGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACG
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42878002/42481996 (Hg38)
End
42878094/42482088 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA22A
Nearest miRNA
hsa-mir-1281/Upstream/558699; hsa-let-7a-3/Downstream/2718866;
Nearest TSS
ENST00000624155/Upstream/43973; ENST00000472589/Downstream/37706;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/112754, chr22-CpG: 77/Downstream/18092
Upstream sequence
agactctatgtccgaaaaaaagaaaaaagagacaggggatcgcgcgctctctcgcgctctcctctctcattcttctcccccctctgccatgtgaggtctg
Downstream sequence
ccagaactgtgagaaacaaatgtctgttgtttgagcctcccagtctaccacatctttagcagccacagcagacgaagacacctgcagtcattgccattgc
Target sequence
aagtaggaaggcagccatgcttaaaaccaggaagaggccctccccagattgaaccgaatcttccagtaccttgatctctaactttccagttt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate