PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017380
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1844
End
1933
Integrated sequence
CTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGC
Host Sequence
Chromosome
chr8
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64986083/64073526 (Hg38)
End
64986179/64073622 (Hg38)
Location type
Intron
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-124-1/Upstream/2358667; hsa-mir-10400/Downstream/305527;
Nearest TSS
ENST00000518652/Upstream/304096; ENST00000524060/Downstream/166660;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/904319, chr8-CpG: 109/Downstream/295724
Upstream sequence
tgagagaagttgaccaatgtgcatacttttacttaaccagctaattagtagaatcagctagttagaatttaaactagatcatctggttccaaCCTCGAGG
Downstream sequence
ATGATCAACTGCAACTCAGGACTTACATACAGCATGGAGTTCTTTATATTTTAAAATATCTGACTTAACTGAATCTTGCCTATTATCCTATTGTTCTATA
Target sequence
GTTCATGGCTACCTATCATGCACAGAGCTTGGAGGTTGTATTCTCAGGAAATTCTCACCTTTTTGGGGCCTTCCTTAGCACTCCAGTTTTACATAA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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