Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017382
Fusion event
HBV-RECK integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
2943
End
3032
Integrated sequence
GGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAG
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
Start
End
36064528/36064531 (Hg38)
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-15b-5p ; hsa-mir-21-5p ; hsa-mir-222-3p ; hsa-mir-15a-5p ; hsa-mir-182-5p ; hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-103a-3p ; hsa-mir-16-5p ; hsa-mir-25-3p ; hsa-mir-374b-5p ; hsa-mir-221-3p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-562 ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-96-5p ; hsa-mir-92b-3p ; hsa-mir-7847-3p ; hsa-mir-1294 ; hsa-mir-6880-5p ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-5192 ; hsa-mir-4722-5p ; hsa-mir-6134 ; hsa-mir-7854-3p ; hsa-mir-4693-3p ; hsa-mir-4768-3p ; hsa-mir-3922-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-5586-3p ; hsa-mir-3714 ; hsa-mir-1271-5p ; hsa-mir-29b-2-5p ; hsa-mir-190a-3p ; hsa-mir-299-5p ; hsa-mir-410-3p ; hsa-mir-646 ; hsa-mir-618 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-503-5p ; hsa-mir-135b-5p ; hsa-mir-15b-3p ; hsa-mir-409-3p ; hsa-mir-590-5p ; hsa-mir-183-5p
Nearest miRNA
hsa-mir-101-2/Upstream/331442; hsa-let-7a-1/Downstream/759008;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/26870, chr9-CpG: 114/Downstream/71660
Nearest cancer related gene
RECK(TSG, No orient, 0)
Upstream sequence
GCTCCTTGTGGCTGTGGGCTCCGCTTGCCGTTTCCTGCAGGAGCAGGGCCACCGGGCCGAGGCCACCACACTGCATGTGGCTCCCCAGGGCACAGCCATG
Downstream sequence
GTTGGAAAGCCTTCTCTTATTTTCTTCTTCTAGGGACTTATCTCAGATAAGAGTATATGAGATATGGTATCACCTTCACTTTCACAGAGACGACTATCCT
Target sequence
AGAGGAAAAACTAGCCTCTTGGTTCCTCTACTGCAAGTGGCAGAAATAGACTTAACTGGGAAACTAGAAGTGGTTAGATGGACCTGAAACCACA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.