Basic Information
VIS ID
TVIS10017384
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1738
End
1826
Integrated sequence
GAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
13832399/13790902 (Hg38)
End
13832496/13790999 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/3396340; hsa-let-7g/Downstream/1705240;
Nearest TSS
ENST00000440867/Upstream/140181; ENST00000432444/Downstream/84114;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/135275, chr3-CpG: 34/Downstream/27938
Nearby gene
TRSUP-CTA2-1(+1487) ;
Upstream sequence
attcatttgaataaataccaaggaacatgattgctggattatgtgataagcatttgtatcattttgtaagaaactgccaaactgtcttccaaagtggctg
Downstream sequence
GGTTCTCCCTCCCGGTAGAGTCAGCAGTGGCTTCCCCTCCCAGTCTCCAGGGCCCTGAAACCACCTTTCTGTCTGATGTGCAGCACGTCTTGCCTCCGAG
Target sequence
CCCCACAGGGCTCTTCAGCCACCCCTTCTGAAGGAGCTGTGTGCTGCCTGCCTGGTCCCATCTTAATCCACCCACTGCCCTTCATGGCCTGGAACTC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate