Basic Information
VIS ID
TVIS10017385
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2096
End
2183
Integrated sequence
AATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGC
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
13832541/13791044 (Hg38)
End
13832638/13791141 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/3396482; hsa-let-7g/Downstream/1705098;
Nearest TSS
ENST00000440867/Upstream/140323; ENST00000432444/Downstream/83972;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/135417, chr3-CpG: 34/Downstream/27796
Nearby gene
TRSUP-CTA2-1(+1345) ;
Upstream sequence
TCCACCACCCCCTGCTAAACTCACCTCCATGCTGGCTTGTTTGACCTTCTGCACCTCAAACACCCTGTGCGGGGTCCCCTGCTGGTAGTTGATGTAGTTC
Downstream sequence
AAGGCCTGAGGTCCTGGTTTTCTCCACAGCTCTGGGAACACCATGGCTTGATGCTGGGGTCTTTGGCACAAAGGGCTTCTCAGAGACCATTGTTCTGTGC
Target sequence
TCCAGGGCCCTGAAACCACCTTTCTGTCTGATGTGCAGCACGTCTTGCCTCCGAGCACGGCCAGCTCCCATGAGTCTTGGCGTCCTCACAGGCTTTG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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