Basic Information
VIS ID
TVIS10017389
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2404
End
2494
Integrated sequence
CTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTT
Host Sequence
Chromosome
chr3
Cytoband
p13
Reference genome
GRCh37/hg19
Start
72613950/72564799 (Hg38)
End
72614049/72564898 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1022710; hsa-mir-12124/Downstream/2649578;
Nearest TSS
ENST00000440867/Upstream/14247; ENST00000498315/Downstream/230692;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/117098, chr3-CpG: 24/Downstream/90274
Upstream sequence
AGAATCATGTATTATTTCAGACTAGAACCTAAAAAAGAGACTCACCAGGTAACAGCCTAGGAAGCTACTGATTATATGTAGTATATAATTATTTGCTGTC
Downstream sequence
tgagggtacagtcgtcccctggtatctgcagggattggttccaggaccccttcagataccaaaatccatggatgctcaggttcctgatataaaaggatat
Target sequence
agagaccttgagccagaaccacttagcaaatcagctcgcaaattctaacctacagaaactatgagatcataaatgtgtgttttttgaagcctttacatt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate