Basic Information
VIS ID
TVIS10017390
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
240
End
331
Integrated sequence
CCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAA
Host Sequence
Chromosome
chr3
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
80940378/80891227 (Hg38)
End
80940478/80891327 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/1383258; hsa-mir-12124/Downstream/4494383;
Nearest TSS
ENST00000440867/Upstream/102264; ENST00000482617/Downstream/102541;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1124477, chr3-CpG: 75/Downstream/869837
Upstream sequence
CTCCAGCCAAGAAAATGCACTTCAGATTAGAAAATGCAAAATAGATTAATTCATATAGAACCAAGAGCCAgccaggtacagtggctcatgcatgtaatct
Downstream sequence
gagggacttctgagtctgaagctacagctaagctgtttcagatttttgattcaaagaaacggagagaaaaataaatgtttgttgctgtaagtcactaagt
Target sequence
tccacagttgaatcccactcacagccagactggaagtggatcatttcccaatcaagccttgagatgaccacagctctaagtacttcgactgtagacttat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate