KDM4C _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017391
Fusion event
HBV-KDM4C integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
3072
End
3161
Integrated sequence
AAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTC
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
7008542/7008542 (Hg38)
End
7008640/7008640 (Hg38)
Location type
Intron
Target gene
KDM4C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-409-3p ; hsa-mir-432-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1000638; hsa-let-7a-1/Downstream/11564666;
Nearest TSS
ENST00000422679/Upstream/24261; ENST00000495890/Downstream/5148;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/249670, chr9-CpG: 43/Downstream/790715
Nearest cancer related gene
KDM4C(OG, No orient, 0)
Upstream sequence
AAATAAATAGCCTGGAAATTTAATTATCATCAGCTTTATGAAAAAGCACACACTATAGCATTCAGAAGATGAGAATGTGTATCAGAACTTATGCATGGAA
Downstream sequence
aggaccacaccagtggaatgttggtgccaagctggcccccgtgaacccaagatcctggcctaactcagtagacccaagcttcagttcttacatggtggac
Target sequence
tagtgaaccctgggtacaggtctaccatagaagaccctggcattgggccaactcccacagaccaaacatccaggaacatccctgtggatgcagttgac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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