Basic Information
VIS ID
TVIS10017393
Fusion event
HBV-chr10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1739
End
1827
Integrated sequence
AGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
108180352/106420594 (Hg38)
End
108180448/106420690 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/2152189; hsa-mir-202/Downstream/4477400;
Nearest TSS
ENST00000439456/Upstream/236209; ENST00000421481/Downstream/186528;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1777540, chr10-CpG: 100/Downstream/743332
Upstream sequence
ATGAACTATGGAGAACAGTAGAAATATGCCAATGTcactgttcacaatagcaaagacttggaaccaatccaaatgcccatcaatgatagagcagataaag
Downstream sequence
cccctccccgctccccccaccccacaacaggccccggtgtatgatgttccccttcctgtgtccatgcattctcattgttcaattcccacctatgagtgag
Target sequence
caaagtacaggttagttacatatgtatacatgtgctatgttgatgtgctgcacccattaactcgtcatttaacattaggtatatctcctaatgcta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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