Basic Information
VIS ID
TVIS10017394
Fusion event
HBV-chr10 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1924
End
2007
Integrated sequence
AATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAG
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
108180484/106420726 (Hg38)
End
108180572/106420814 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/2152321; hsa-mir-202/Downstream/4477276;
Nearest TSS
ENST00000439456/Upstream/236341; ENST00000421481/Downstream/186404;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1777672, chr10-CpG: 100/Downstream/743208
Upstream sequence
ATATAGCAGCTTGACATTTCACAGAACAAAACATCTCCTCCTATGTGGAGTGTGCCTGTTCTGACAATACTAAAGACCTAGTTTGCCATGGTTACTTTGT
Downstream sequence
cttgcaatagtttgctgagaatgatggtttccagcttcatccatgtccctacaaaggacatgaactcatcattttttatggctgcatagtatttcatggt
Target sequence
gtgtatgatgttccccttcctgtgtccatgcattctcattgttcaattcccacctatgagtgagaacatgcggtgcttggtttttgtc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate