Basic Information
VIS ID
TVIS10017395
Fusion event
HBV-MCUB integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1477
End
1569
Integrated sequence
GGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCT
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
110533873/109612717 (Hg38)
End
110533974/109612818 (Hg38)
Location type
Intron
Target gene
MCUB
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-324-3p
Nearest miRNA
hsa-mir-12113/Upstream/123922; hsa-mir-1243/Downstream/1247764;
Nearest TSS
ENST00000502981/Upstream/51727; ENST00000494604/Downstream/71622;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/51813, chr4-CpG: 76/Downstream/89985
Upstream sequence
TGGCCTCTATTAACAAGTGTTATTAAGAAATTAGGTTTGTTATGGGCAAATGGATTAACACtataaataatttattttttgtagtataaattattttGAA
Downstream sequence
gaattaggccgggtgcggtgtctcacgcctgtaatcccagcactttgggaggccaaggcgggcggatcacaaggtcaggagatcaagaccatcctggcta
Target sequence
atatttaatccataacaGAAGACCTGGGATgacttccagtaaaagatggcaggcttgacaaatacataaatttccttcctgaaatcctaataagaatacag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate