Basic Information
VIS ID
TVIS10017396
Fusion event
HBV-MCUB integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1916
End
2007
Integrated sequence
TTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAG
Host Sequence
Chromosome
chr4
Cytoband
q25
Reference genome
GRCh37/hg19
Start
110533994/109612838 (Hg38)
End
110534090/109612934 (Hg38)
Location type
Intron
Target gene
MCUB
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-324-3p
Nearest miRNA
hsa-mir-12113/Upstream/124043; hsa-mir-1243/Downstream/1247648;
Nearest TSS
ENST00000502981/Upstream/51848; ENST00000494604/Downstream/71506;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/51934, chr4-CpG: 76/Downstream/89869
Upstream sequence
ttgttttcaataaaactcttcctgttctgcaaaatccttgaagcaaggaaatacagaaggctgggcaacactcgtgaaatgataaggcagaggtgaaaaa
Downstream sequence
tctctactaaaaatataaaaaattagctgggtgtggtggcgggcgtctgtagtcccagctactcgcgaggctgaagcaggagaatggtgtgaacccggga
Target sequence
tctcacgcctgtaatcccagcactttgggaggccaaggcgggcggatcacaaggtcaggagatcaagaccatcctggctaacacggtgaaatcccg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate