Basic Information
VIS ID
TVIS10017397
Fusion event
HBV-SIMC1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
BC
Reference genome
NC_003977
Start
2918
End
3010
Integrated sequence
AGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTG
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
175721194/176294191 (Hg38)
End
175721295/176294292 (Hg38)
Location type
Intron
Fragile sites / regions
FRA5G
Target gene
SIMC1
miRNAs that regulate target gene
hsa-mir-1226-3p
Nearest miRNA
hsa-mir-10397/Upstream/1542404; hsa-mir-1229/Downstream/73654;
Nearest TSS
ENST00000502646/Upstream/23961; ENST00000481515/Downstream/1831;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/55167, chr5-CpG: 58/Downstream/67026
Upstream sequence
tgggccggggacccgggaggggtcgggacggggcggggtccgcgcggaggaggcggagctggaaggtgaaggggcaggacgggTGCCCGGGTCCCCAGTC
Downstream sequence
gttttgatttggagtctcgctctgtcacctaggctggagtgcagtggcgccatcttggttcactgcagcctccaccttccgggtttaagcaattctcatg
Target sequence
aaatcatgttatatgtacaattttgaattctgattttttaactttatatgagctttttcccatgtcattaaaagtttttTAGATAAAGCTCttttttgtct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate