Basic Information
VIS ID
TVIS10017398
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
BC
Reference genome
NC_003977
Start
2327
End
2417
Integrated sequence
ACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGT
Host Sequence
Chromosome
chr8
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
43821030/43965887 (Hg38)
End
43821129/43965986 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/1069612; hsa-mir-10400/Downstream/17748802;
Nearest TSS
ENST00000518652/Upstream/769719; ENST00000518278/Downstream/2856251;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/688552, chr8-CpG: 41/Downstream/2651381
Upstream sequence
TCCTCCCAGCCTAGCATTTGGGCTTCCTAAAACCTATTCCAAAGATTTCACTTCACACGTAAGTTTTttccttccatgtgccttttgcttcagccaggag
Downstream sequence
tctaagaaacatcttagggatgtttacattcaagtcacagagttgaacattccctttcacagagcaggtttgaaacaatcttctcgtactatctggaagt
Target sequence
aaacattctttttatagaatctggaagtggatatttggaaagctttgaggatttcgttggaaacgggaatatcttcaaataaaatctagccagaagcat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate