Basic Information
VIS ID
TVIS10017400
Fusion event
HBV-chr15 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
18
End
108
Integrated sequence
CAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCT
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
55166634/54874436 (Hg38)
End
55166729/54874531 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/2597236; hsa-mir-11181/Downstream/498409;
Nearest TSS
ENST00000557528/Upstream/262961; ENST00000569661/Downstream/182216;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/1114629, chr15-CpG: 52/Downstream/322013
Upstream sequence
TCATGTTTAACATGGGCGTGTATCCCATTTTCGTCTCAAATAAGCAGCTAATTACAAGCATATTCACTCAAAGAAGAACTGATTTTCAATTTAGACCTGC
Downstream sequence
cactcaaagccgctcaactacatggaaactgaacaacctgctcctgaatgactactgggtacataacgaaatgaaggcagaaaaaaagatgttctttgaa
Target sequence
aaagctctcctcagcaaatgtaaaatagtagaaattacaacaaactgtctctcagaccacagtgcaatcaaactagaactgaggatgaagaaact
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate