Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017407
Fusion event
HBV-FGFR1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Start
864
End
944
Integrated sequence
ACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAAT
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
Start
End
38269260/38411742 (Hg38)
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-133b ; hsa-mir-124-3p ; hsa-mir-744-5p ; hsa-mir-296-3p ; hsa-mir-181b-5p ; hsa-mir-10a-5p ; hsa-mir-214-3p ; hsa-mir-149-5p ; hsa-mir-149-3p ; hsa-mir-503-5p ; hsa-mir-198 ; hsa-mir-7977 ; hsa-mir-561-5p ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-6890-3p ; hsa-mir-296-5p ; hsa-mir-573 ; hsa-mir-1226-3p ; hsa-mir-1249-5p ; hsa-mir-185-5p ; hsa-mir-3160-3p ; hsa-mir-3619-5p ; hsa-mir-3665 ; hsa-mir-3689d ; hsa-mir-4306 ; hsa-mir-4419a ; hsa-mir-4487 ; hsa-mir-4510 ; hsa-mir-4530 ; hsa-mir-4644 ; hsa-mir-4792 ; hsa-mir-5192 ; hsa-mir-558 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6134 ; hsa-mir-634 ; hsa-mir-6515-5p ; hsa-mir-6731-5p ; hsa-mir-6760-5p ; hsa-mir-6797-5p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-761 ; hsa-mir-7847-3p ; hsa-mir-7854-3p ; hsa-mir-8077 ; hsa-mir-8085
Nearest miRNA
hsa-mir-124-1/Upstream/8454314; hsa-mir-10400/Downstream/2859306;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/24485, chr8-CpG: 32/Downstream/54459
Nearest cancer related gene
FGFR1(OG, No orient, 0)
Upstream sequence
agaagagagggtacctgacctctcttagttggtcagggaaggaatgtaggaagagttgatgttgaagctgggtctggtcagtaaaagagggaggttgcca
Downstream sequence
GGCAGAAGTAAATTCCAAGCAGCCAAAAAACCAAAAACATTCGGAGAATTTTCCCCCCGTTCCTGAGGGACAGGATGGAGTTTGGACAGGAAGAACTGTA
Target sequence
CGACTGAGGAGTGGTAGTTTGAGCCATGAGGTACGGGGGAGCCAGAATCCACTTAGTGAGGACAGTGATGACCAGCAGGT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.