Basic Information
VIS ID
TVIS10017408
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
736
End
828
Integrated sequence
TTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTAT
Host Sequence
Chromosome
chr8
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
111470459/110458230 (Hg38)
End
111470559/110458330 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/5973765; hsa-mir-10400/Downstream/2185163;
Nearest TSS
ENST00000518652/Upstream/108623; ENST00000523264/Downstream/150911;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/482387, chr8-CpG: 21/Downstream/2974267
Upstream sequence
ttaaATAGAACACTTTATTACAGTGAGATGCTGCCTGGAGAGGGGATACCTGGAAGGGAAGGCCCTGTTTGTGGCAGAAGGGGATGGGAATACAGGTGCA
Downstream sequence
CTCTTCCCCTTCTTCTCCAAAAGAAATTTTACTCACAGAATGTGAGTCTATTCTCTCTTACCGTTTCTAGCATATCGTTATGCTTAAGCCATTTTTCTAT
Target sequence
TAGTCTGGGATCCTGCATAGCAGAGTCTCAATTACCTTCATAACTGACATTAGATTTGTGCTTCCTTTTTGCCTCTATCTTTTGTGTATCAGTGAAAGAT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate