VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10017411

Fusion event

HBV-DNAH9 integration

Validated

No

Detection method

Capture-NGS platform

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2019

PubMed ID

30070724

Virus Sequence

Virus name

HBV

Subtype

B

Reference genome

NC_003977

Start

1138

End

1229

Integrated sequence

GAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATC

Host Sequence

Chromosome

chr17

Cytoband

p12

Reference genome

GRCh37/hg19

Start

11674103/11770786 (Hg38)

End

11674194/11770877 (Hg38)

Location type

Intron

Fragile sites / regions

FRA17A

Target gene

DNAH9

miRNAs that regulate target gene

hsa-mir-665 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-7160-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-5582-5p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-1273e ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-4451 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4468 ; hsa-mir-6840-3p ; hsa-mir-4459 ; hsa-mir-4756-3p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-129-5p ; hsa-mir-4524a-3p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-4797-5p ; hsa-mir-5007-5p ; hsa-mir-7855-5p

Nearest miRNA

hsa-mir-1253/Upstream/3583782; hsa-mir-10226/Downstream/311022;

Nearest TSS

ENST00000595228/Upstream/47677; ENST00000578834/Downstream/82315;

Nearest CpG islands

None/Target, chr17-CpG: 26/Upstream/171775, chr17-CpG: 67/Downstream/226248

Upstream sequence

tcaactcaaagctttgaaccctcctatggatagtgcagttttgaatctctctttttgtggaatctgcaagtggatatgtggtactctttgaagttgtctt

Downstream sequence

aatttccatggtgtaaatactcccaccgtggccaattgtaagctaccaatgcaatgtcagtgaacaaggagtcaggaagagatacacagtagcacaccat

Target sequence

atacttttaagtataatctgtattattaacattttccttatattttcacaagtctacaaaacaaatcaaaccctggtttgtggtgtttgcc

Reference

Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.