Basic Information
VIS ID
TVIS10017412
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2059
End
2141
Integrated sequence
CTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCG
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
71146771/71850944 (Hg38)
End
71146844/71851017 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/12147241; hsa-mir-103a-1/Downstream/318450;
Nearest TSS
ENST00000502646/Upstream/131365; ENST00000504183/Downstream/256217;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/131056, chr5-CpG: 160/Downstream/256033
Upstream sequence
CTGAGCAGCTCGACGACGTACACACTCATCAGCCAGTGCAGGAACTTGGCCAGGATCTCCTCACGCAGACGGTGCTCTGCGGCCGGAACACAGCCAACCC
Downstream sequence
gagagaggggcccgtgccttggaaagcgtcgcggttctggcggcatccggtgagctctcgctggcccttgaaaatccgggggagagggtgtaaatctcaa
Target sequence
aagccggcgggagccccggggagagttctcttttctttgtgaagggcagggcgccctggaatgggttcgcccc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate