Basic Information
VIS ID
TVIS10017413
Fusion event
HBV-chr5 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2168
End
2259
Integrated sequence
CAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGG
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
165072150/165645145 (Hg38)
End
165072249/165645244 (Hg38)
Location type
Intron
Nearest miRNA
hsa-mir-10397/Upstream/5159695; hsa-mir-103a-1/Downstream/2520601;
Nearest TSS
ENST00000502646/Upstream/296115; ENST00000520075/Downstream/483254;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2139205, chr5-CpG: 17/Downstream/1333235
Upstream sequence
gccccgTCCAGCAGCGCGAAGCCGAAGGCCAGCACGTTCTTCGCGCCGCGCTCGCACAGCCTCTGCAGCACTCGGGCCACCAGCTCCTTCAGGCAGGACA
Downstream sequence
CTTTCCAAGTTGTTTGTTTTCCGGCAGGTACAATCCTATGTTTCATGTTATTTGGTGTTTTATGCATCTCTCTTTAAATAGACTCTGTAGAACTGGAGGG
Target sequence
tttgattcaagaacctgcaactccacctagtcagttctttgcctctttgTTATGCCACTCTGTATTTTACCCTTCCCCTACTCTCCAAACCGAGTCTTA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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