Basic Information
VIS ID
TVIS10017415
Fusion event
HBV-AOPEP integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
117
End
207
Integrated sequence
TCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGG
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
97656709/94894427 (Hg38)
End
97656797/94894515 (Hg38)
Location type
Intron
Target gene
AOPEP
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-6820-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6087 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6510-5p ; hsa-mir-6089 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-518f-3p ; hsa-mir-518c-3p ; hsa-mir-518d-3p ; hsa-mir-518b ; hsa-mir-518a-3p ; hsa-mir-6849-3p ; hsa-mir-4293 ; hsa-mir-6771-3p ; hsa-mir-3180-5p ; hsa-mir-2355-5p ; hsa-mir-1236-3p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-4793-5p ; hsa-mir-510-5p ; hsa-mir-4786-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-1193 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-1224-3p ; hsa-mir-2392 ; hsa-mir-1306-5p ; hsa-mir-1343-3p ; hsa-mir-23a-5p ; hsa-mir-23b-5p ; hsa-mir-4264 ; hsa-mir-4279 ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-498 ; hsa-mir-622 ; hsa-mir-660-3p ; hsa-mir-6727-3p ; hsa-mir-6742-3p ; hsa-mir-6747-3p ; hsa-mir-6783-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p
Nearest miRNA
hsa-let-7a-1/Upstream/84370; hsa-mir-12126/Downstream/170835;
Nearest TSS
ENST00000422679/Upstream/133989; ENST00000473778/Downstream/25700;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/167537, chr9-CpG: 164/Downstream/109852
Upstream sequence
CTAGTCTAAATTCCCAGCTGTGGATTTCCTATGACACCATGGCTTTGTACTGAAACAGTTAAGTCACATTTACAGGGTGACATGTAAAAACAGCAACAGC
Downstream sequence
aattattagacaacctaagtaaacaatacccatggaagaaagttagcaaagaatttttcctggaaaaacaccagacccacagagtttctttcataagtga
Target sequence
tgaacttttcagcaaagaattttgacaatctgactgaaataaatgattttctaagaacatatgagtcaccaaaaattgataccgaatg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate