Basic Information
VIS ID
TVIS10017416
Fusion event
HBV-chrX integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
908
End
950
Integrated sequence
TTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTA
Host Sequence
Chromosome
chrX
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
89714251/90459252 (Hg38)
End
89714348/90459349 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/4555545; hsa-mir-105-1/Downstream/4603792;
Nearest TSS
ENST00000429181/Upstream/537296; ENST00000418369/Downstream/848432;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/4310379, chrX-CpG: 43/Downstream/975254
Upstream sequence
TTTTAAAagcacttggcacatagtagatgcttaagaaatgttCTGCAGCCAAATAAAAATAACTTAGAAGAAGACCTTGACATCACTATTAAAATAAAAT
Downstream sequence
atgtttcaggaaagtagagtggaaattacaaggtacagattctattgctgcatctaccagtgtgctatgtgatcttgagcaatcatttattccttctgac
Target sequence
gctaatctctctcaATGGAAAGAATTAACAGAAATGTTTTACTGCCCCTTGCTCTGCTATGTATGTCTGTGTATATGAGTATGCATTGGAaagcaat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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