PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017417
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1725
End
1815
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
85640386/85066251 (Hg38)
End
85640485/85066350 (Hg38)
Location type
Intron
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-1297/Upstream/7368135; hsa-mir-1267/Downstream/2552315;
Nearest TSS
ENST00000623511/Upstream/503887; ENST00000424926/Downstream/12570;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1186489, chr13-CpG: 121/Downstream/2604964
Upstream sequence
tacagaaccctctaccccaaatcaacagaacatacattcttctccatgccacattccacttattgtaaaatcgaccacataattggaagtaaaacactcc
Downstream sequence
TTCAGGAAAACTTACTTTTGTTAAATTCATTTATTATACACATAGAGAAAATATTGCAGCTGAAACTGAGTCCTATAATGCAGTCATATAATGAAGTAAG
Target sequence
TTAGATAATAGAATAGCTGAAATCACAAATGAAACGGCATGTAGAATATACCACTCAGGAAAATCAAGTTGCTGTTTTCAAAATATACCTATTAACTCC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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