Basic Information
VIS ID
TVIS10017418
Fusion event
HBV-LOC100506016 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
531
End
620
Integrated sequence
ACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCC
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
112814718/112160404 (Hg38)
End
112814816/112160502 (Hg38)
Location type
Intronic
Target gene
LOC100506016
Nearest miRNA
hsa-mir-1267/Upstream/1819375; hsa-mir-4502/Downstream/1102418;
Nearest TSS
ENST00000623511/Upstream/53285; ENST00000561786/Downstream/36848;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/53605, chr13-CpG: 112/Downstream/3000
Upstream sequence
ACCATGGCATGGATGATGACTTTCTATAATAGTTCAGGGTTCCAAAACACTATATGTATTGTATTTCAAATAACTTGTTTCTGGGTCTTGCATAGTTTGT
Downstream sequence
TTTGTTCTTACCCATACAGAAAGCAAAAAGTTAAAATACTAAATTTTCCCTTGTTCTTATCTTTTCCCTTTGCAGCTGCCGTTTTCTGGTATTCAAGGGT
Target sequence
CACATGCTTCTGCTAACAGGACTGTCAGCTCCTGGCGTGCTCCAACCCCTGTCCTGTGCCTTTGATCACCCAATTAGCCTGCCCTCTGTTTCTGGGGT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate