Basic Information
VIS ID
TVIS10017419
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2880
End
2971
Integrated sequence
TGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGG
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
46388200/34583611 (Hg38)
End
46388297/34583706 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/419938; hsa-mir-11401/Downstream/15708910;
Nearest TSS
ENST00000527434/Upstream/423575; ENST00000319817/Downstream/396138;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/82155, chr16-CpG: 276/Downstream/218136
Upstream sequence
ccatttgattccattcgaccatgattgcctttgattccattcaatgactccattcggttccttttgatgatgattccgttcgattccatttcattattcc
Downstream sequence
cgatgattccattggattccattcgatgatgattccattcaaatccattcgataattcaattcaagtccattcgatgatgattccaatcgaatccattca
Target sequence
gataattgcattcgattccattctatgatgattccattcgagtccatttgatgattccattcaattcaagtcaatgatgattccattcgattccact
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate