Basic Information
VIS ID
TVIS10017423
Fusion event
HBV-MIR29B2CHG integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1737
End
1823
Integrated sequence
GGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
207996201/207822856 (Hg38)
End
207996267/207822922 (Hg38)
Location type
Intron
Target gene
MIR29B2CHG
Nearest miRNA
hsa-mir-101-1/Upstream/20333; hsa-mir-1182/Downstream/1609211;
Nearest TSS
ENST00000473358/Upstream/153; ENST00000638446/Downstream/46228;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/70237, chr1-CpG: 94/Downstream/45595
Upstream sequence
gaaatgtcagcaagtccagccaggggtttacggacaaaactctgatctcccttgggaatggagccactaaggagaggggcaaccacaacctctgtaaatc
Downstream sequence
GAAGGGAGCCAACATGGAGACACAGAGAGCGCAAGGTAAACAACTTTCCAACGCCAAAAGGATGACATTTAATCTCTAAATGCTAGCTTCCCTTCTTAGC
Target sequence
GGAAGGCCAGCTCAGTCACTTAGTTAATGATGCAGCAGTACAGGGAAGGCCATCACATGTGAACTG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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