Basic Information
VIS ID
TVIS10017424
Fusion event
HBV-MIR29B2CHG integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2630
End
2698
Integrated sequence
AATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAAC
Host Sequence
Chromosome
chr1
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
207996150/207822805 (Hg38)
End
207996237/207822892 (Hg38)
Location type
Intron
Target gene
MIR29B2CHG
Nearest miRNA
hsa-mir-101-1/Upstream/20282; hsa-mir-1182/Downstream/1609241;
Nearest TSS
ENST00000473358/Upstream/102; ENST00000638446/Downstream/46258;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/70186, chr1-CpG: 94/Downstream/45625
Upstream sequence
gtgagattcgccccagtgcagacagcccctccaccaaagagcaggcagagttcttcattaaaagggtccctgatcccgtgcctcctgactggatgagaca
Downstream sequence
AGTACAGGGAAGGCCATCACATGTGAACTGGAAGGGAGCCAACATGGAGACACAGAGAGCGCAAGGTAAACAACTTTCCAACGCCAAAAGGATGACATTT
Target sequence
CACCCACCAATCAGAGGAAGTGTCTGGAGGGAGAGCCCTCCCCTGGCCAATGGAAGGCCAGCTCAGTCACTTAGTTAATGATGCAGC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate