GLI1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017425
Fusion event
HBV-GLI1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1162
End
1275
Integrated sequence
ACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGC
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57856179/57462396 (Hg38)
End
57856297/57462514 (Hg38)
Location type
Promoter
Target gene
GLI1
miRNAs that regulate target gene
hsa-mir-326 ; hsa-mir-125b-5p ; hsa-mir-324-5p ; hsa-mir-335-5p ; hsa-mir-202-3p ; hsa-mir-133b
Nearest miRNA
hsa-mir-1228/Upstream/267820; hsa-let-7i/Downstream/50174;
Nearest TSS
ENST00000382841/Upstream/1883; ENST00000527742/Downstream/1178;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/218506, chr12-CpG: 99/Downstream/12778
Nearest cancer related gene
GLI1(TSG, No orient, 0)
Upstream sequence
agtgtgtgtgtacatgagtatatgtgagagagagattgtgtgtgAGGGGTGGCCCATGAACAAAGGCCCACAACAAGGCTATTTTTTAAAATTTGTTTTG
Downstream sequence
GGAGTTTGAAAAGAAAAACGGACAGCAGCACCTTCTTCCTCGCTACGCTTTTATAAGGATCACATTGTTTTTTTCATTCTCTCAGAGTCTCCCCTCATAC
Target sequence
CCCGGGATCACCCAccgcgccggccggcccggcccgcTCCCGGTGGTTCTccaccccatcccgccccaccccacccTCATTCCCGGGAGACTGGAAAACCCGGGATGGAGTCAAAACT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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