PRSS50 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017429
Fusion event
HBV-PRSS50 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
102
End
211
Integrated sequence
ACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTT
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
46755825/46714335 (Hg38)
End
46755943/46714453 (Hg38)
Location type
Exon
Target gene
PRSS50
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-12127/Upstream/1852354; hsa-let-7g/Downstream/1135102;
Nearest TSS
ENST00000440867/Upstream/13002; ENST00000490109/Downstream/3454;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/12739, chr3-CpG: 51/Downstream/3121
Upstream sequence
GTAAAGCTCACTGGCCTGGGAGTTGCCTCTATCTGCCAACCTTTGGCCAGTGAAGAGGATTCAGAGAAAATAATACAACCATCAATCAGAAAAAGGAGGG
Downstream sequence
TGGTCAATCCACGGACTCCCCACCCTCACTGAGTAGATAACATCACGCCTAGGGGGGCCGTGAGGGGAGGCCATGATCAGCTCCAGGCCCCCTGCCCCAG
Target sequence
GAGCTTGAGGAGGCCGATGTCGTTGGCCTGGCCCACCCAGGACCAGAACCGCTGGGCCCGGTACCTGCTATGCATGATGACCTGGAGCACCGGGACATCGGAGGCGGTCTGCGTCATC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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