PRSS50 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017430
Fusion event
HBV-PRSS50 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1985
End
2100
Integrated sequence
AGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGA
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
46755960/46714470 (Hg38)
End
46756084/46714594 (Hg38)
Location type
Exon
Target gene
PRSS50
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-12127/Upstream/1852489; hsa-let-7g/Downstream/1134961;
Nearest TSS
ENST00000440867/Upstream/13137; ENST00000490109/Downstream/3313;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/12874, chr3-CpG: 51/Downstream/2980
Upstream sequence
cataccacatttttactgtaacttttctgtatttagatacacaaatacttacagttacacacagtattcagtacagtaatatgctgtgcaggtttgtagc
Downstream sequence
AGATCCAGGAGGGGCCACCCACCCGCTTCAAGCCCCCTGAGCCTACTCCTCACCACAGACATGAACAGGGCCCTGCACACTCACTGTGTGGtccagtcct
Target sequence
CCCCACCCTCACTGAGTAGATAACATCACGCCTAGGGGGGCCGTGAGGGGAGGCCATGATCAGCTCCAGGCCCCCTGCCCCAGCCTCCAGCCTGGGCCTTCCCCCACTCTGCTGCCCTCCCAGA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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