VISDB Viral Integration Site DataBase

VIS ID

TVIS10017438

Fusion event

AAV2-CCNE1 integration

Validated

No

Detection method

WES

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2018

PubMed ID

Virus name

AAV2

Reference genome

Start

4253

End

4590

Integrated sequence

GGAGCTGCAGAAGGAAAACAGCAAACGCTGGAATCCCGAAATTCAGTACACTTCCAACTACAACAAGTCTGTTAATGTGGACTTTACTGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAGTTGAACTTTGGTCTCTGCGTATTTCTTTCTTATCTAGTTTCCATGGCTACGTAGATAAGTA

Chromosome

chr19

Cytoband

q12

Reference genome

Start

End

30303740/29812836 (Hg38)

Location type

Intron

Target gene

miRNAs that regulate target gene

hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b

Nearest miRNA

hsa-mir-10395/Upstream/9413479; hsa-let-7e/Downstream/5309864;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/59, chr19-CpG: 21/Downstream/30697

Nearest cancer related gene

CCNE1(OG, No orient, 0)

Upstream sequence

aggccttcgttggaaacgggtttttttcttgtaaggctagacagaagaattctcagtaacttccttgtgttgtgtgtattcaactcacggagttgaacgt

Downstream sequence

CTTGGCTCTGCCTACGGGGGCGGGGGTCCCTTGGGCAGGAACGGAGCTCATAACCTGATCAGCTTTCTCTTCTTCTCTCTGTTTTTGTCTTGTTTGGTGT

Target sequence

CTT