VISDB Viral Integration Site DataBase

VIS ID

TVIS10017457

Fusion event

HBV-APOA1 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

X protein;

Start

1694

Integrated sequence

CTCTGCACGTCGCATGGAGACCACCGTGAACGCCCGACAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGAC| |CTTGAGGCATACTTCAAAGACTGTGTATTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAAT

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

116708112/116837396 (Hg38)

Location type

5UTR

Fragile sites / regions

FRA11G ; FRA11B

Target gene

miRNAs that regulate target gene

hsa-mir-6869-5p ; hsa-mir-558 ; hsa-mir-3158-5p ; hsa-mir-4740-3p ; hsa-mir-135b-5p ; hsa-mir-135a-5p ; hsa-mir-4747-5p ; hsa-mir-5196-5p ; hsa-mir-3202 ; hsa-mir-3179 ; hsa-mir-3663-3p ; hsa-mir-181d-3p ; hsa-mir-6722-5p ; hsa-mir-1305 ; hsa-mir-627-3p ; hsa-mir-1289 ; hsa-mir-3135b ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-431-5p ; hsa-mir-924

Nearest miRNA

hsa-mir-10392/Upstream/3387308; hsa-let-7a-2/Downstream/1806604;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/1202, chr11-CpG: 117/Downstream/260426

Upstream sequence

agaaaatttttgcaatctgtccatctgacaaaggtcaatatccagcatctataaaaaacttaaatttacaagaaaaaaacaaccccattaaaaagtgggg

Downstream sequence

CAATAAAATCCATCTGTTAACACTGTGATAGAAAAAATAATCAGTCCACATCATGTAATAAAAACAGGCTTTGAGGATGATTATACCTCTTATAATAAAA