UNC13C _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017466
Fusion event
HBV-UNC13C integration
Validated
No
Detection method
TS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2016
PubMed ID
26867494
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
DQ089769.1
Region type
core protein;X protein;
Start
1833
Integrated sequence
GAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTGGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTG| |CCTAATCATCTCATGTTCATGTCCCACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCT
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
54464920/54172723 (Hg38)
End
54464920/54172723 (Hg38)
Location type
Intronic
Target gene
UNC13C
miRNAs that regulate target gene
hsa-mir-128-3p
Nearest miRNA
hsa-mir-10393/Upstream/1895523; hsa-mir-11181/Downstream/1200217;
Nearest TSS
ENST00000557528/Upstream/159819; ENST00000561210/Downstream/91422;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/412916, chr15-CpG: 52/Downstream/1023821
Upstream sequence
aatagacatctacagaactctccaccccaaatcaacagaatatacatttttttcagcaccaaatcacacctgttccaaaattgaccatatagttggaagt
Downstream sequence
atatatatatatatatatatatatatatatatatatatCTTTACTCTATAGGTCAttttgggtcttgtctaagaagtatatccctaccccatggttgtga
Reference
Chiu, Y. T., et al. Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma. J Hepatol ,2016,64(6): 1256-1264.
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