VISDB Viral Integration Site DataBase

VIS ID

TVIS10017468

Fusion event

HBV-MSRB1 integration

Validated

No

Detection method

TS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2016

PubMed ID

Virus name

HBV

Subtype

C

Reference genome

Region type

core protein;Polymerase;

Start

2449

Integrated sequence

ACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGT| |TAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGACTGGCAAACTCCCTCTTTTCCTCAC

Chromosome

chr16

Cytoband

p13.3

Reference genome

Start

End

1989144/1939143 (Hg38)

Location type

Exonic

Target gene

miRNAs that regulate target gene

hsa-mir-149-5p ; hsa-mir-5096 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-548s ; hsa-mir-6832-5p ; hsa-mir-4755-3p ; hsa-mir-296-3p ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-6793-3p ; hsa-mir-937-5p ; hsa-mir-3145-5p ; hsa-mir-122-5p ; hsa-mir-1304-3p ; hsa-mir-143-5p ; hsa-mir-216a-5p ; hsa-mir-216b-5p ; hsa-mir-3135b ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-504-3p ; hsa-mir-5698 ; hsa-mir-6499-3p ; hsa-mir-6736-3p ; hsa-mir-6787-3p

Nearest miRNA

hsa-mir-3176/Upstream/204077; hsa-mir-11401/Downstream/151052;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/8852, chr16-CpG: 84/Downstream/3524

Upstream sequence

GCTTTTTTGTGGATTTGCAGTTTAATTGTTTTCTTTACTTGTTCTGTGATTTATTAACATTGTTTAGCAAAAACAATGTTTTCTTTTTTTTAAAAAAAGA

Downstream sequence

CTGAAAGAGAGGAGAGGGGGCGGAAAGTATGCGGGGACAGAAAGCAAGCAGGGGCGGAAAGCCGGGCGCGGGGGCGGTGGAAAGCCAGGGTAGGGGCAGA